msmbuilder.SCRE.FixEntry¶

msmbuilder.SCRE.FixEntry(mapping, parameters, populations, K0, i, j, Val)[source]¶

Constrain an entry in a rate matrix.

Parameters:	mapping : list List of (i,j) indices that have already been constrained. parameters : list List of rate matrix elements K[i,j]. populations : ndarray Equilibrium populations i : int j : int Val : float Constrain the value K[i,j] = Val.

Notes

Also constrains the transpose entry by detailed balance. Removes the entry from the lists of free variables (mapping, parameters).